Katsuya Hirasaka Selected Research

Ligases (Synthetase)

9/2022	Morin improves dexamethasone-induced muscle atrophy by modulating atrophy-related genes and oxidative stress in female mice.
1/2022	MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.
1/2021	Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes.
1/2018	Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.
3/2017	Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance.
1/2016	Dietary Supplementation with Isoflavones Prevents Muscle Wasting in Tumor-Bearing Mice.
3/2015	N-myristoylated ubiquitin ligase Cbl-b inhibitor prevents on glucocorticoid-induced atrophy in mouse skeletal muscle.
1/2014	Ubiquitin ligase Cbl-b and obesity-induced insulin resistance.
1/2013	Soy Glycinin Contains a Functional Inhibitory Sequence against Muscle-Atrophy-Associated Ubiquitin Ligase Cbl-b.
1/2013	Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation.

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Katsuya Hirasaka Research Topics

Disease

16	Muscular Atrophy (Muscle Atrophy) 12/2023 - 02/2009
13	Atrophy 09/2022 - 03/2004
8	Neoplasms (Cancer) 12/2018 - 09/2009
6	Body Weight (Weight, Body) 09/2022 - 08/2007
6	Lymphoma (Lymphomas) 01/2021 - 02/2003
5	Infections 09/2023 - 09/2009
5	Colorectal Neoplasms (Colorectal Cancer) 04/2018 - 01/2015
3	Colonic Neoplasms (Colon Cancer) 04/2018 - 01/2015
3	Insulin Resistance 01/2016 - 10/2007
3	Obesity 01/2014 - 02/2009
2	Inflammation (Inflammations) 10/2022 - 01/2013
2	Edema (Dropsy) 07/2020 - 02/2007
2	Rigor Mortis 10/2019 - 10/2019
2	Disease Progression 01/2017 - 01/2015
2	Hypoxia (Hypoxemia) 01/2015 - 01/2015
1	Bacterial Infections (Bacterial Infection) 07/2020
1	Pneumonia (Pneumonitis) 07/2020
1	Pneumococcal Infections 07/2020
1	Lung Injury 07/2020
1	Hypersensitivity (Allergy) 01/2020
1	Cachexia 12/2018
1	Carcinoma (Carcinomatosis) 12/2018
1	Myocardial Infarction 11/2018
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Chronic Disease (Chronic Diseases) 05/2015
1	Muscular Diseases (Myopathy) 05/2015

Drug/Important Bio-Agent (IBA)

15	UbiquitinIBA 09/2022 - 10/2006
15	Ligases (Synthetase)IBA 09/2022 - 10/2006
7	Proteins (Proteins, Gene)FDA Link 12/2023 - 08/2007
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2018 - 01/2015
5	CytokinesIBA 01/2016 - 08/2007
4	AntioxidantsIBA 01/2021 - 04/2008
4	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2017 - 01/2015
3	FlavonoidsIBA 09/2022 - 12/2018
3	morinIBA 09/2022 - 12/2018
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 03/2004
3	daidzeinIBA 12/2018 - 01/2013
3	GenisteinIBA 12/2018 - 01/2013
3	IsoflavonesIBA 12/2018 - 01/2013
3	Angiogenesis InhibitorsIBA 01/2017 - 01/2015
3	Insulin (Novolin)FDA Link 06/2013 - 10/2007
3	Caseins (Casein)FDA Link 05/2012 - 09/2009
3	Messenger RNA (mRNA)IBA 05/2012 - 09/2009
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2009 - 02/2003
2	Dexamethasone (Maxidex)FDA LinkGeneric 09/2022 - 01/2021
2	Muscle Proteins (Muscle Protein)IBA 09/2022 - 01/2021
2	GlucocorticoidsIBA 01/2021 - 03/2015
2	Adenosine Triphosphate (ATP)IBA 10/2019 - 10/2019
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2018 - 01/2016
2	LipidsIBA 11/2018 - 01/2016
2	Sunitinib (Sutent)FDA Link 04/2018 - 01/2017
2	Tyrosine Kinase InhibitorsIBA 04/2018 - 01/2015
2	regorafenibIBA 01/2017 - 01/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 10/2007
2	QuercetinIBA 01/2016 - 02/2009
2	Interleukin-6 (Interleukin 6)IBA 01/2016 - 09/2009
2	Soybean Proteins (Soy Protein)IBA 01/2015 - 08/2006
2	Insulin-Like Growth Factor I (IGF-1)IBA 12/2012 - 05/2006
2	Cathepsin GIBA 01/2010 - 09/2009
2	Peroxidase (Myeloperoxidase)IBA 01/2010 - 09/2009
2	TeaIBA 02/2009 - 04/2008
1	CCAAT-Enhancer-Binding Protein-betaIBA 09/2023
1	LipopolysaccharidesIBA 10/2022
1	Transcription Factors (Transcription Factor)IBA 09/2022
1	astaxanthine (astaxanthin)IBA 01/2021
1	Lipid Bilayers (Lipid Bilayer)IBA 01/2021
1	F-Box ProteinsIBA 01/2021
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 01/2021
1	Therapeutic UsesIBA 07/2020
1	Polysaccharides (Glycans)IBA 07/2020
1	FibrinIBA 07/2020
1	Interleukin-12 (IL 12)IBA 07/2020
1	ascophyllinIBA 07/2020
1	MetalsIBA 01/2020
1	ActomyosinIBA 10/2019
1	Myosins (Myosin)IBA 10/2019
1	ribosomal protein S10IBA 12/2018
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 11/2018
1	Dietary Fiber FDA Link 11/2018
1	Neuropilin-1IBA 04/2018
1	Bevacizumab (Avastin)FDA Link 04/2018
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2017
1	LigandsIBA 01/2017
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2017
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2016
1	Uncoupling Protein 3IBA 01/2016
1	pyruvate dehydrogenase kinase 4IBA 01/2016
1	OligopeptidesIBA 05/2015
1	atelocollagenIBA 05/2015
1	GSK 1363089IBA 01/2015
1	Monoclonal AntibodiesIBA 01/2015
1	Vascular Endothelial Growth Factor BIBA 01/2015
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2014
1	Peptides (Polypeptides)IBA 01/2013
1	glycininIBA 01/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013

Therapy/Procedure

5	Therapeutics 04/2018 - 01/2015
3	Denervation 01/2013 - 05/2006
2	Bed Rest (Bedrest) 12/2012 - 12/2012
1	Oral Administration 07/2020